Publications Archive - KalVista Pharmaceuticals

Global Frequency, Diagnosis, and Treatment of Hereditary Angioedema with Normal C1 Inhibitor

Markus Magerl, Marc Riedl, Luisa Karla Arruda, Andrea Bauer, Alejandro Berardi, Jonathan Bernstein, Laurence Bouillet, Matthew Buckland, Thomas Buttgereit, Danny Cohn, Timothy Craig, Roberta Criado, Aurélie Du-Thanh, Olivier Fain, Margarida Gonçalo, Jens Greve, Anete Sevciovic Grumach, Mar Guilarte, Constance Katelaris, Tamar Kinaciyan, Elena Latysheva, Ramon Lleonart, Oscar Calderón Llosa, Eli Mansour, Vesna Grivcheva-Panovska, Claudio Parisi, Nelson Augusto Rosario Filho, Amélia Spínola Santos, Petra Staubach, Anna Valerieva, Solange Oliveira Rodrigues Valle, Sherry Danese, Julie Ulloa, Paul Audhya, Marcus Maurer

J Allergy Cli Immunol Global. 2025 August; 4(3)100446. Online ahead of print.

Interplay of On-demand Trials for Hereditary Angioedema Attacks and Treatment Guidelines

Danny Cohn, Daniel Soteres, Timothy Craig, William Lumry, Markus Magerl, Marc Riedl, Paul Audhya, Marcus Maurer, Jonathan Bernstein

J Allergy Clin Immunol. 2025 Mar;155(3):726-739

Indirect Treatment Comparison of Oral Sebetralstat and Intravenous Recombinant Human C1 Esterase Inhibitor for On-demand Treatment of Hereditary Angioedema Attacks

H. Henry Li, Emel Aygören-Pürsün, Markus Magerl, Timothy Craig, Michael Manning, Noemi Hummel, Agnieszka Kopiec, Shuai Fu, James Morris, Alice Wang, Paul Audhya, Jonathan Bernstein

Allergy Asthma Clin Immunol. 2025 Mar 15;21(1):10

On-demand Treatment of Hereditary Angioedema Attacks: Patient-reported Utilization, Barriers, and Outcomes

Sandra Christiansen, Maeve O’Connor, Timothy Craig, Cristine Radojicic, James Wedner, Sherry Danese, Julie Ulloa, Vibha Desai, Christopher Utter, Tomas Andriotti, Paul Audhya, Paula Busse

Ann Allergy Asthma Immunol. 2024 Dec 16:S1081-1206(24)01732-0. Online ahead of print.

Advent of Oral Medications for the Treatment of Hereditary Angioedema

Anna Valerieva, Teresa Caballero, Markus Magerl, Joao Frade, Paul Audhya, Timothy Craig

Clin Transl Allergy. 2024 Sep;14(9):e12391

Closing Gaps in Hereditary Angioedema Management: Addressing Delays in On-demand Treatment

Douglas Jones

EMJ Allergy Immunol. 2024 Jul;9(1):37-43

Oral Sebetralstat for On-demand Treatment of Hereditary Angioedema Attacks

Marc Riedl, Henriette Farkas, Emel Aygören-Pürsün, Fotis Psarros, Daniel Soteres, Maria Staevska, Mauro Cancian, David Hagin, Daisuke Honda, Isaac Melamed, Sinisa Savic, Marcin Stobiecki, Paula Busse, Eunice Dias de Castro, Nancy Agmon-Levin, Richard Gower, Aharon Kessel, Marcin Kurowski, Ramon Lleonart, Vesna Grivcheva-Panovska, James Wedner, Paul Audhya, James Hao, Matthew Iverson, Michael Smith, Christopher Yea, William Lumry, Andrea Zanichelli, Jonathan Bernstein, Marcus Maurer, and Danny Cohn for the KONFIDENT Investigators

N Engl J Med. 2024 Jul 4;391(1):32-43

The Complexities of Decision-Making Associated with On-Demand Treatment of Hereditary Angioedema (HAE) Attacks

Stephen Betschel, Teresa Caballero, Douglas Jones, Hilary Longhurst, Michael Manning, Sally van Kooten, Markus Heckmann, Sherry Danese, Ledia Goga, Autumn Burnette

Allergy Asthma Clin Immunol. 2024 Jul 25;20(1):43

Sebetralstat: A Rapidly Acting Plasma Kallikrein Inhibitor for the On-demand Treatment of Hereditary Angioedema

Edward Feener, Rebecca Davie, Nivetha Murugesan, Stephen Pethen, Sally Hampton, Michael Smith, Paul Audhya, Christopher Yea

Drugs Drug Candidates 2024 Apr;3(2): 328-341

Real-world Reporting Rates of Administration-site Reactions with On-demand Treatment of Hereditary Angioedema Attacks

Raffi Tachdjian, Sinisa Savic, Moshe Fridman, Joao Frade, Marie Fasehun, Paul Audhya

Allergy Asthma Proc. 2024 Jan 22;45(1):37-43

Oral Factor XIIa Inhibitor KV998086 Suppresses FXIIa and Single Chain FXII Mediated Kallikrein Kinin System Activation

Allen Clermont, Nivetha Murugesan, Hannah Edwards, Daniel Lee, Natasha Bayliss, Edward Duckworth, Stephen Pethen, Sally Hampton, David Gailani, Edward Feener

Front Pharmacol. 2023 Dec 19:14:1287487

Evaluation of Patient-reported Outcome Measures for On-demand Treatment of Hereditary Angioedema Attacks and Design of KONFIDENT, a Phase 3 trial of Sebetralstat

Danny Cohn, Emel Aygören-Pürsün, Jonathan Bernstein, Henriette Farkas, William Lumry, Marcus Maurer, Andrea Zanichelli, Matthew Iverson, James Hao, Michael Smith, Christopher Yea, Paul Audhya, Marc Riedl

Clin Transl Allergy. 2023 Sep;13(9):e12288

Hereditary Angioedema with Normal C1 Inhibitor: US Survey of Prevalence and Provider Practice Patterns

Marc Riedl, Mark Danese, Sherry Danese, Julie Ulloa, Andreas Maetzel, Paul Audhya

J Allergy Clin Immunol Pract. 2023 Aug;11(8):2450-2456.e6

Titanium is a Potent Inducer of Contact Activation: Implications for Intravascular Devices

Maxim Litvak, Aleksandr Shamanaev, Sandip Zalawadiya, Anton Matafonov, Anton Kobrin, Edward Feener, Michael Wallisch, Erik Tucker, Owen McCarty, David Gailani

J Thromb Haemost. 2023 May;21(5):1200-1213

An Investigational Oral Plasma Kallikrein Inhibitor for On-demand Treatment of Hereditary Angioedema: A Two-part, Randomized, Double-blind, Placebo-controlled, Crossover Phase 2 Trial

Emel Aygören-Pürsün, Andrea Zanichelli, Danny Cohn, Mauro Cancian, Roman Hakl, Tamar Kinaciyan, Markus Magerl, Inmaculada Martinez-Saguer, Marcin Stobiecki, Henriette Farkas, Sorena Kiani-Alikhan, Vesna Grivcheva-Panovska, Jonathan Bernstein, H Henry Li, Hilary Longhurst, Paul Audhya, Michael Smith, Christopher Yea, Andreas Maetzel, Daniel Lee, Edward Feener, Richard Gower, William Lumry, Aleena Banerji, Marc Riedl, Marcus Maurer

Lancet. 2023 Feb;401(10375):458-469

Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential On-demand Treatment for Hereditary Angioedema

Rebecca Davie, Hannah Edwards, D Michael Evans, Simon Hodgson, Stocks, Alun Smith, Louise Rushbrooke, Stephen Pethen, Michael Roe, David Clark, Paul McEwan, Sally Hampton

J Med Chem. 2022 Oct 27;65(20):13629-13644

Pharmacological Suppression of the Kallikrein Kinin System with KVD900: An Orally Available Plasma Kallikrein Inhibitor for the On-demand Treatment of Hereditary Angioedema

Edward Duckworth, Nivetha Murugesan, Lily Li, Louise Rushbrooke, Daniel Lee, Gian Marco De Donatis, Andreas Maetzel, Christopher Yea, Sally Hampton, Edward Feener

Clin Exp Allergy. 2022 Sep;52(9):1059-1070

Absorption, Metabolism and Excretion of Sebetralstat (KVD900) Following a Single Oral Dose in Healthy Male Participants

Peter Mutch, Mohammad Bashir, Bonnie Jung, Ping Yi, Matt Iverson

Xenobiotica. 2022 Jul;52(7):707-717

KVD900, An Oral On-demand Treatment for Hereditary Angioedema; Phase 1 Study Results

Andreas Maetzel, Michael Smith, Edward Duckworth, Sally Hampton, Gian Marco De Donatis, Nivetha Murugesan, Louise Rushbrooke, Lily Li, Danielle Francombe, Edward Feener, Christopher Yea

J Allergy Clin Immunol. 2022 Jun;149(6):2034-2042

A Mechanism for Hereditary Angioedema Caused by a Lysine 311-to-glutamic Acid Substitution in Plasminogen

Kent Dickeson, Sunil Kumar, Mao-Fu Sun, Bassem Mohammed, Dennis Phillips, James Whisstock, Adam Quek, Edward Feener, Ruby Law, David Gailani

Blood. 2022 May 5;139(18):2816-2829

Plasma Kallikrein Contributes to Intracerebral Hemorrhage and Hypertension in Stroke-Prone Spontaneously Hypertensive Rats

Jian Guan, Allen Clermont, Loc-Duyen Pham, Tuna Ustunkaya, Alexey Revenko, A Robert MacLeod, Edward Feener, Fabrício Simão

Transl Stroke Res. 2022 Apr;13(2):287-299

Polyphosphate Expression by Cancer Cell Extracellular Vesicles Mediates Binding of Factor XII and Contact Activation

Young Jun Shim, Victor Chatterjee, Shadi Swaidani, Ravi Kumar Alluri, Suman Kundu, Alona Merkullova, Dana Angelini, Dewen You, Samantha Whitney, Edward Feener, John Barnard, Alvin Schmaier, Alok Khorana, Keith McCrae

Blood Adv. 2021 Nov 23;5(22):4741-4751

One-time Intravitreal Injection of KVD001, a Plasma Kallikrein Inhibitor, in Patients with Central-involved Diabetic Macular Edema and Reduced Vision: An Open-label Phase 1B Study

Jennifer Sun, Raj Maturi, David Boyer, John Wells, Victor Gonzalez, Robert Tansley, Helen Hernandez, Lloyd Aiello

Ophthalmol Retina. 2019 Dec;3(12):1107-1109

Plasma Kallikrein Mediates Brain Hemorrhage and Edema Caused by Tissue Plasminogen Activator Therapy in Mice After Stroke

Fabricio Sinao, Tuna Ustunkaya, Allen Clermont, Edward Feener

Blood. 2017 Apr 20;129(16):2280-2290

Plasma Kallikrein Mediates Vascular Endothelial Growth Factor-Induced Retinal Dysfunction and Thickening

Allen Clermont, Nivetha Murugesan, Qunfang Zhou, Tasheka Kita, Peter Robson, Louise Rushbrooke, D Michael Evans, Lloyd Aiello, Edward Feener

Invest Ophthalmol Vis Sci. 2016 May 1;57(6):2390-9

Plasma Kallikrein-Kinin System as a VEGF-dependent Mediator of Diabetic Macular Edema

Takeshi Kita, Allen Clermont, Nivetha Murugesan, Qunfang Zhou, Kimihiko Fujisawa, Tatsuro Ishibashi, Lloyd Aiello, Edward Feener

Diabetes. 2015 Oct;64(10):3588-99

Intraocular Hemorrhage Causes Retinal Vascular Dysfunction Via Plasma Kallikrein

Jia Liu, Allen Clermont, Ben-bo Gao, Edward Feener

Invest Ophthalmol Vis Sci. 2013 Feb 7;54(2):1086-94

Plasma Kallikrein Mediates Retinal Vascular Dysfunction and Induces Retinal Thickening in Diabetic Rats

Allen Clermont, Tamie Chilcote, Tasheki Kita, Jia Lui, Pricilla Riva, Sukanto Sinha, Edward Feener

Diabetes. 2011 May;60(5):1590-8

Hyperglycemia-induced Cerebral Hematoma Expansion is Mediated by Plasma Kallikrein

Jia Liu, Ben-bo Gao, Allen Clermont, Price Blair, Tamie Chilcote, Sukanto Sinha, Robert Flaumenhaft, Edward Feener

Nat Med. 2011 Feb;17(2):206-10

Plasma Kallikrein and Diabetic Macular Edema

Edward Feener

Curr Diab Rep. 2010 Aug;10(4):270-5

Plasma Kallikrein Mediates Angiotensin II Type 1 Receptor-Stimulated Retinal Vascular Permeability

Joanna Phipps, Allen Clermont, Sukanto Sinha, Tamie Chilcote, Sven-Erik Bursell, Edward Feener

Hypertension. 2009 Feb;53(2):175-81

The Kallikrein-kinin System in Diabetic Retinopathy: Lessons for the Kidney

Joanna Phipps, Edward Feener

Kidney Int. 2008 May;73(10):1114-9

Extracellular Carbonic Anhydrase Mediates Hemorrhagic Retinal and Cerebral Vascular Permeability Through Prekallikrein Activation

Ben-bo Gao, Allen Clermont, Susan Rook, Stephanie Fonda, Vivek Srinivasan, Maciej Wojkowski, James Fugimoto, Robert Avery, Paul Arrigg, Sven-Erik Bursell, Lloyd Aiello, Edward Feener

Nat Med. 2007 Feb;13(2):181-8

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