Search term examples: EAACI, 2025, KONFIDENT

MEDICAL INFORMATION INQUIRIES
+1 85K.ALV.ISTA
(+1 855.258.4782)
medinfo@kalvista.com

SELECT PUBLICATIONS

Showing 10 of 10

Interplay of On-demand Trials for Hereditary Angioedema Attacks and Treatment Guidelines

Danny Cohn, Daniel Soteres, Timothy Craig, William Lumry, Markus Magerl, Marc Riedl, Paul Audhya, Marcus Maurer, Jonathan Bernstein

J Allergy Clin Immunol. 2025 Mar;155(3):726-739

Advent of Oral Medications for the Treatment of Hereditary Angioedema

Anna Valerieva, Teresa Caballero, Markus Magerl, Joao Frade, Paul Audhya, Timothy Craig

Clin Transl Allergy. 2024 Sep;14(9):e12391

Oral Sebetralstat for On-demand Treatment of Hereditary Angioedema Attacks

Marc Riedl, Henriette Farkas, Emel Aygören-Pürsün, Fotis Psarros, Daniel Soteres, Maria Staevska, Mauro Cancian, David Hagin, Daisuke Honda, Isaac Melamed, Sinisa Savic, Marcin Stobiecki, Paula Busse, Eunice Dias de Castro, Nancy Agmon-Levin, Richard Gower, Aharon Kessel, Marcin Kurowski, Ramon Lleonart, Vesna Grivcheva-Panovska, James Wedner, Paul Audhya, James Hao, Matthew Iverson, Michael Smith, Christopher Yea, William Lumry, Andrea Zanichelli, Jonathan Bernstein, Marcus Maurer, and Danny Cohn for the KONFIDENT Investigators

N Engl J Med. 2024 Jul 4;391(1):32-43

Sebetralstat: A Rapidly Acting Plasma Kallikrein Inhibitor for the On-demand Treatment of Hereditary Angioedema

Edward Feener, Rebecca Davie, Nivetha Murugesan, Stephen Pethen, Sally Hampton, Michael Smith, Paul Audhya, Christopher Yea

Drugs Drug Candidates 2024 Apr;3(2): 328-341

Evaluation of Patient-reported Outcome Measures for On-demand Treatment of Hereditary Angioedema Attacks and Design of KONFIDENT, a Phase 3 trial of Sebetralstat

Danny Cohn, Emel Aygören-Pürsün, Jonathan Bernstein, Henriette Farkas, William Lumry, Marcus Maurer, Andrea Zanichelli, Matthew Iverson, James Hao, Michael Smith, Christopher Yea, Paul Audhya, Marc Riedl

Clin Transl Allergy. 2023 Sep;13(9):e12288

An Investigational Oral Plasma Kallikrein Inhibitor for On-demand Treatment of Hereditary Angioedema: A Two-part, Randomized, Double-blind, Placebo-controlled, Crossover Phase 2 Trial

Emel Aygören-Pürsün, Andrea Zanichelli, Danny Cohn, Mauro Cancian, Roman Hakl, Tamar Kinaciyan, Markus Magerl, Inmaculada Martinez-Saguer, Marcin Stobiecki, Henriette Farkas, Sorena Kiani-Alikhan, Vesna Grivcheva-Panovska, Jonathan Bernstein, H Henry Li, Hilary Longhurst, Paul Audhya, Michael Smith, Christopher Yea, Andreas Maetzel, Daniel Lee, Edward Feener, Richard Gower, William Lumry, Aleena Banerji, Marc Riedl, Marcus Maurer

Lancet. 2023 Feb;401(10375):458-469

Sebetralstat (KVD900): A Potent and Selective Small Molecule Plasma Kallikrein Inhibitor Featuring a Novel P1 Group as a Potential On-demand Treatment for Hereditary Angioedema

Rebecca Davie, Hannah Edwards, D Michael Evans, Simon Hodgson, Stocks, Alun Smith, Louise Rushbrooke, Stephen Pethen, Michael Roe, David Clark, Paul McEwan, Sally Hampton

J Med Chem. 2022 Oct 27;65(20):13629-13644

Pharmacological Suppression of the Kallikrein Kinin System with KVD900: An Orally Available Plasma Kallikrein Inhibitor for the On-demand Treatment of Hereditary Angioedema

Edward Duckworth, Nivetha Murugesan, Lily Li, Louise Rushbrooke, Daniel Lee, Gian Marco De Donatis, Andreas Maetzel, Christopher Yea, Sally Hampton, Edward Feener

Clin Exp Allergy. 2022 Sep;52(9):1059-1070

Absorption, Metabolism and Excretion of Sebetralstat (KVD900) Following a Single Oral Dose in Healthy Male Participants

Peter Mutch, Mohammad Bashir, Bonnie Jung, Ping Yi, Matt Iverson

Xenobiotica. 2022 Jul;52(7):707-717

KVD900, An Oral On-demand Treatment for Hereditary Angioedema; Phase 1 Study Results

Andreas Maetzel, Michael Smith, Edward Duckworth, Sally Hampton, Gian Marco De Donatis, Nivetha Murugesan, Louise Rushbrooke, Lily Li, Danielle Francombe, Edward Feener, Christopher Yea

J Allergy Clin Immunol. 2022 Jun;149(6):2034-2042

SELECT PUBLICATIONS

About

Science

Pipeline

Careers

Contact